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With Roc2, Cul5EY mutants develop normally and do not display any overt morphological defects. That Roc2 and Cul5 mutant animals are viable and display no obvious developmental defects is consistent with our analysis of Roc-Cullin interactions indicating that Roc2 and Cul5 bind exclusively to each other. Indeed, Roc2 and Cul5 accumulation in vivo is interdependent: Roc2 was undetectable in Cul5 mu

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