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However, it is very unstable, showing a half-life of ?1?s (Fig.?2C; Movies?S3 and S4 in Supporting Information). In the mps3-sun mutant, the clustering of Rap1 foci is also seen, but with a reduced frequency (Fig.?2D). At 3?h, 18% of the mutant cells show clustering, which is roughly one-half of that seen in wild type. This difference is statistically significant (Mann�CWhitney U-test, P?
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Used. With the current knowledge on the mixed effect on diseases, it might be feasible to find a representative cohort of new menopausal women without HT for follow-up studies.8.9.10. 11.Conclusion There was a notable variability in the development of disturbing vasomotor symptoms over time in a selected group of women aged 50 -59. Population-based followup studies of untreated women would be use
Was 67 kg (range: 48?03 kg). There were 13 Caucasians, three Thais, one Black, one Asian Indian, one Mulatto and one Cape Coloured. PK parameters are presented in Figure 1. The mean half-life and mean clearance remained largely unchanged after repeated daily dosing for 14 or 28 days. There was no accumulation of MICA between day 1 and the end of therapy beyond that expected for a drug with linear
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